DNA Damage Response
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
HUS1 is a core DNA damage checkpoint clamp component (9-1-1 complex), USP3 is a deubiquitinase that regulates histone H2A/H2B ubiquitination at DNA damage sites, BCLAF1 participates in DNA damage-induced apoptosis and RNA processing, KDM5C is a histone H3K4 demethylase involved in chromatin regulation, ZER1 is a substrate receptor for CRL2 ubiquitin ligase involved in chromatin. SIRT3 regulates mitochondrial protein acetylation and oxidative stress. CNPY3 is a chaperone for TLR folding. The module shows mild non-significant upregulation in inflammation. Overall the module reflects DNA damage response and chromatin regulation programs.
Genes
Most correlated modules
- DNA Damage Response · correlation 0.89
- Cellular Housekeeping Mixed · correlation 0.86
- General Housekeeping · correlation 0.86
- Ubiquitin-Chromatin Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.