General Housekeeping
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include DLST and ACO2 (TCA cycle enzymes), IMPDH2 (purine biosynthesis), RALY, SF3B4, AAR2, DDX47 (RNA processing), and DYRK1A (kinase). The module is uniformly expressed at low levels with no disease association, suggesting a general housekeeping program combining metabolic maintenance and RNA processing. No subset enrichment and flat disease deltas support a constitutive housekeeping identity.
Genes
Most correlated modules
- Cellular Housekeeping Mixed · correlation 0.92
- DNA Damage Response · correlation 0.89
- RNA & Protein Homeostasis · correlation 0.86
- DNA Damage Response · correlation 0.86
- Endosomal Trafficking · correlation 0.82
- LXR/PPAR Repression · correlation 0.82
- PI3K-Wnt Signaling · correlation 0.82
- Ubiquitin-Chromatin Regulation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.