DNA Damage Response
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes include STAG1 (cohesin, chromosome cohesion), PPP2CA (PP2A phosphatase, cell cycle regulation), CDK8 (mediator kinase, transcription/cell cycle), CDKN1A (p21/CIP1, CDK inhibitor), FBXO42 (F-box ubiquitin ligase), PNKP and TDP1 (DNA strand break repair), NUP153 (nuclear pore, cell cycle-linked), SMURF1 (ubiquitin ligase), POGZ (chromatin/mitosis). The cohesin (STAG1), CDK8, CDKN1A, and DNA repair genes collectively point to a DNA damage response and cell cycle checkpoint program. Elevated delta_inflammation_UC (0.902) may reflect genotoxic stress in inflamed tissue.
Genes
Most correlated modules
- General Housekeeping · correlation 0.89
- DNA Damage Response · correlation 0.89
- Endosomal Trafficking · correlation 0.88
- ER Protein Quality Control · correlation 0.86
- Cellular Housekeeping Mixed · correlation 0.86
- RNA & Protein Homeostasis · correlation 0.86
- Ubiquitin-Chromatin Regulation · correlation 0.84
- Endosomal Autophagy Trafficking · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.