Ubiquitin-Chromatin Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include ASMTL, CGGBP1 (CGG-repeat binding/chromatin), SIAH1 (E3 ubiquitin ligase, stress/hypoxia response), PPM1B (PP2C phosphatase, stress signaling), SMARCB1 (SWI/SNF chromatin remodeling), USP7 (deubiquitinase), RFFL (E3 ligase), TAPBP (tapasin, MHC-I antigen loading), VAMP3 (SNARE, vesicle fusion/degranulation-related), RAB22A (endosomal trafficking), SBNO2 (anti-inflammatory transcription factor), DEDD (death effector domain apoptosis). The combination of ubiquitin pathway (SIAH1, USP7, RFFL), chromatin remodeling (SMARCB1, CGGBP1), and immune-related genes (TAPBP, SBNO2) suggests a stress-linked ubiquitin/chromatin regulatory program. Mild UC inflammation association supports immune context.
Genes
Most correlated modules
- DNA Damage Response · correlation 0.84
- Endosomal Trafficking · correlation 0.84
- BRD4 Chromatin Regulation · correlation 0.82
- General Housekeeping · correlation 0.80
- DNA Damage Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.