Cytoskeletal Trafficking
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include TRIO (Rho GEF activating Rac1/RhoA, cytoskeletal remodeling), MYO9B (myosin IXB with intrinsic Rho GAP activity, regulates actin cytoskeleton), TNS1 (tensin, focal adhesion and actin linkage), DYNC1H1 (cytoplasmic dynein heavy chain, intracellular transport along microtubules), PACS1 (membrane trafficking/sorting endosomes), GNPTAB (GlcNAc-1-phosphotransferase, lysosomal enzyme targeting), and ITGAX (CD11c integrin). The module combines cytoskeletal remodeling (TRIO, MYO9B, TNS1, DYNC1H1) with vesicular/lysosomal trafficking (PACS1, GNPTAB). CD46 is a complement regulatory protein. Mild CD inflammation signal. This reflects intracellular trafficking and cytoskeletal organization programs in mast cells.
Genes
Most correlated modules
- Purinergic Receptor Signaling · correlation 0.87
- Eicosanoid Biosynthesis · correlation 0.86
- Mast Cell Activation Signaling · correlation 0.86
- Actin-driven Migration · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.