Eicosanoid Biosynthesis
Gene co-expression module in Mast cells
| Category | Eicosanoid metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 25 genes have a known function matching the annotation |
Why this annotation
ALOX5 encodes 5-lipoxygenase, the rate-limiting enzyme for leukotriene biosynthesis. PTGS1 encodes COX-1, essential for prostaglandin synthesis. Together these define the eicosanoid metabolism program. KIT and SIGLEC6 are canonical mast cell identity markers confirming cell type. NDST2 and HS6ST1 are heparan sulfate biosynthesis enzymes critical for mast cell granule heparin. BMPR1A may modulate mast cell responses. This module strongly represents the eicosanoid/arachidonic acid metabolic program in mast cells, consistent with their role in inflammatory lipid mediator production.
Genes
Most correlated modules
- Mast Cell Activation Signaling · correlation 0.88
- Mast Cell Specification · correlation 0.88
- Epigenetic Transcriptional Control · correlation 0.87
- Cytoskeletal Trafficking · correlation 0.86
- Ubiquitin-Lysosomal Maintenance · correlation 0.86
- Mast Cell Activation · correlation 0.84
- Mast Cell Identity · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.