Transcriptional Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 34 genes have a known function matching the annotation |
Why this annotation
Hub genes include RHEB (mTOR pathway activator), CDK20 (cyclin-dependent kinase), HAT1 (histone acetyltransferase), TAF2 (TFIID basal transcription), NR2C2 (nuclear receptor/transcriptional repressor), UBE2R2 (ubiquitin E2 conjugating enzyme), ABL1 (tyrosine kinase), DAZAP1 (RNA-binding), CHERP (splicing). The module centers on transcriptional regulation and chromatin modification with mTOR signaling input. Flat disease response and uniform expression indicate a constitutive transcriptional regulation program.
Genes
Most correlated modules
- Mixed Splicing Stress · correlation 0.77
- Pre-mRNA Splicing · correlation 0.70
- Protein Biogenesis Housekeeping · correlation 0.69
- Transcriptional Regulation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.