Pre-mRNA Splicing
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 24 genes have a known function matching the annotation |
Why this annotation
Top hub genes CWC25 (splicing factor, CWC complex), BUD31 (spliceosome component, Prp45 homolog), and AKAP8 (nuclear scaffold involved in pre-mRNA splicing) point to spliceosome/RNA processing. PNO1 is involved in ribosome biogenesis. DNAJB6 is a chaperone. NFKBIB (IκBβ) links this module to the NF-κB neighborhood (M182, M62). PLK3 is a stress-activated kinase. SPOP is a ubiquitin ligase adaptor involved in protein quality control. The module is mixed but RNA splicing dominates the top-ranked hub genes. Low mean expression and pct positive suggest a less active program.
Genes
Most correlated modules
- NF-κB Activation · correlation 0.80
- NF-κB Inflammatory Signaling · correlation 0.79
- Mixed Splicing Stress · correlation 0.76
- RNA Splicing · correlation 0.76
- Transcriptional Regulation · correlation 0.76
- RNA-binding Regulation · correlation 0.75
- TGF-beta Repression · correlation 0.74
- Cytokine Receptor Signaling · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.