Mixed Splicing Stress
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 31 genes have a known function matching the annotation |
Why this annotation
This module has low mean expression and low detection rate. It contains a heterogeneous set of genes. PRPF38B is a pre-mRNA splicing factor. MAGOHB is part of the exon junction complex. MFAP1 is involved in pre-mRNA splicing. PPIG is a peptidyl-prolyl isomerase involved in splicing. RPP38 is part of RNase P. KIF5B is a kinesin motor protein. ADRM1 is a proteasome ubiquitin receptor. TNF is a major pro-inflammatory cytokine. MAP3K13 is a kinase in the NF-κB pathway. ATG101 is involved in autophagy initiation. MANF is an ER stress-responsive neurotrophic factor. MTMR9 is a myotubularin-related phosphatase. DDA1 is a proteasome-associated protein. LACTB is a mitochondrial serine beta-lactamase. BTN2A2 is an immune checkpoint molecule. This module is mixed, combining splicing factors (PRPF38B, MAGOHB, MFAP1, PPIG, RPP38) with immune/stress genes (TNF, MAP3K13, ATG101, MANF). Given the neighbor context (M29 is also splicing-heavy), the splicing component is likely real, but the module is poorly defined. The presence of TNF and MAP3K13 adds an inflammatory flavor. Overall, this appears to be a mixed module with splicing and stress/inflammatory components.
Genes
Most correlated modules
- Protein Biogenesis Housekeeping · correlation 0.78
- Transcriptional Regulation · correlation 0.77
- Pre-mRNA Splicing · correlation 0.76
- Mast Cell Activation · correlation 0.76
- Proteostasis & Translation · correlation 0.72
- Chromatin Transcriptional Regulation · correlation 0.69
- RNA Splicing · correlation 0.65
- Mitotic Spindle · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.