Protein Biogenesis Housekeeping
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include YWHAE (14-3-3ε signaling scaffold), PFDN2 (prefoldin chaperone complex), SSB (La antigen RNA binding), NAP1L1 (nucleosome assembly protein), MRPL14 (mitochondrial ribosomal protein), EIF5A (translation initiation/elongation factor), ABCF1 (ABC transporter involved in translation), DDX21 (RNA helicase/ribosome biogenesis), TXN (thioredoxin redox), SDF2L1 (ER stress/unfolded protein response), UBE2M (SUMO E2 conjugating enzyme). The module combines translation initiation (EIF5A, ABCF1), RNA processing (SSB, DDX21), and chaperone/protein folding (PFDN2, SDF2L1) functions — a general housekeeping/protein biogenesis program. Uniform expression across subsets supports a constitutive housekeeping role.
Genes
Most correlated modules
- RNA-binding Regulation · correlation 0.87
- NF-κB Inflammatory Signaling · correlation 0.81
- Mixed Splicing Stress · correlation 0.78
- Chromatin Transcriptional Regulation · correlation 0.74
- Housekeeping Maintenance · correlation 0.72
- Mast Cell Activation · correlation 0.71
- Proteostasis & Translation · correlation 0.70
- Pre-mRNA Splicing · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.