Transcriptional Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZNF207, KMT5C (H4K20me3 methyltransferase), ZNF672, GMEB2, ILF2, DHX9, TFDP1, and SIAH2 — a mix of zinc finger transcription factors, chromatin regulators, RNA helicases, and ubiquitin ligases. The module is uniformly expressed across all subsets with moderate-to-strong membership, suggesting a housekeeping transcriptional/chromatin maintenance program rather than a cell-state-specific response. SREBF1 and SPTLC2 add a lipid metabolic component, but the dominant theme is general transcriptional and epigenetic regulation. No strong inflammatory, stress, or lineage-specific signal is present.
Genes
Most correlated modules
- Pre-mRNA Splicing · correlation 0.76
- p38-MK2 Stress Signaling · correlation 0.75
- Histone Ubiquitination · correlation 0.74
- TGF-beta Repression · correlation 0.70
- S-phase Histones · correlation 0.65
- Transcriptional Regulation · correlation 0.64
- RNA Splicing · correlation 0.62
- Mixed Splicing Stress · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.