Mitochondrial Protein Import
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 31 genes have a known function matching the annotation |
Why this annotation
This module has high mean expression (0.990) and detection rate (57.4%), consistent with a broadly expressed housekeeping program. Hub genes include TOMM20 (translocase of outer mitochondrial membrane 20, mitochondrial protein import), PEBP1 (phosphatidylethanolamine-binding protein 1, Raf kinase inhibitor), FAM162A (mitochondria-associated, hypoxia-induced), SELENOW (selenoprotein W, antioxidant), NACA (nascent polypeptide-associated complex alpha, co-translational), PFDN5 (prefoldin subunit 5, chaperone), EIF3E and EIF3H and EIF3G (eukaryotic initiation factor 3 subunits, translation initiation), TOMM7 (translocase of outer mitochondrial membrane 7), CHCHD10 (mitochondrial intermembrane space protein), LAPTM4A (lysosomal protein transmembrane), RAB34 (Rab GTPase, vesicle trafficking), RSL24D1 (ribosome biogenesis), SNRPN (snRNP, splicing). The dominant theme is mitochondrial protein import (TOMM20, TOMM7, CHCHD10, FAM162A) combined with translation initiation (EIF3E, EIF3H, EIF3G, NACA) and chaperone function (PFDN5). This is a housekeeping/mitochondrial biogenesis and translation program. The neighbor M80 contains mast cell identity genes, and M51 has mitochondrial components, supporting a housekeeping neighborhood. The module is not disease-responsive.
Genes
Most correlated modules
- Vesicle Trafficking Secretion · correlation 0.84
- Mitochondrial Organization · correlation 0.78
- Mast Cell Identity · correlation 0.77
- tRNA Aminoacylation · correlation 0.76
- Mast Cell Activation · correlation 0.76
- General Housekeeping · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.