Heat Shock Response
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 25 genes have a known function matching the annotation |
Why this annotation
This module is dominated by heat shock proteins and chaperones, all with core or strong membership. HSPA1A, HSPA1B, HSPA8 (HSP70 family), HSPH1 (HSP110), HSP90AA1 (HSP90), HSPD1 (HSP60), HSPE1 (HSP10), DNAJB1, DNAJB4, DNAJA1, DNAJA4 (HSP40/DNAJ co-chaperones), CHORDC1 (HSP90 co-chaperone), AHSA1 (HSP90 activator), STIP1 (HSP70/HSP90 organizing protein), FKBP4 (HSP90 co-chaperone), TCP1 (chaperonin). Additional genes: ZFAND2A (stress-induced ubiquitin-like protein), SERTAD1 (cell cycle/stress), MRPL18 (mitochondrial ribosome), EIF5 (translation initiation). This is a highly coherent heat shock/proteotoxic stress response module. The mild upregulation in UC inflammation is consistent with cellular stress in the inflamed colon environment.
Genes
Most correlated modules
- RNA Splicing · correlation 0.73
- Inflammatory Mast Activation · correlation 0.55
- Leukotriene Biosynthesis · correlation 0.50
- Co-transcriptional RNA Processing · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.