Co-transcriptional RNA Processing
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include SCAF11 (splicing-associated factor), DNAJC7 (HSP40/DnaJ co-chaperone that assists HSP70), ZC3H13 (component of the MACOM m6A RNA methylation complex), CAMLG (calcium signal modulator linked to lymphocyte activation), AKAP9 (A-kinase anchoring protein, centrosome/Golgi scaffold), CDK13 (cyclin-dependent kinase involved in transcription elongation and RNA splicing), RILP (Rab7-interacting lysosomal protein), GGPS1 (geranylgeranyl pyrophosphate synthase, isoprenoid/prenylation pathway), ING3 (inhibitor of growth, HAT complex), FOXP1 (transcription factor). The module is mixed but DNAJC7 as a prominent chaperone co-chaperone, alongside ZC3H13 (m6A), SCAF11 (splicing), and CDK13 (splicing kinase) suggests a co-transcriptional RNA processing and chaperone program. Higher mean expression (0.593) and pct positive (36.2%) than neighbors suggests broader constitutive activity.
Genes
Most correlated modules
- Mast Cell Degranulation · correlation 0.74
- Chromatin Transcriptional Regulation · correlation 0.71
- Leukotriene Biosynthesis · correlation 0.68
- Mast Cell Activation · correlation 0.68
- Housekeeping Maintenance · correlation 0.60
- RNA Splicing · correlation 0.58
- Heat Shock Response · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.