RNA Splicing
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 33 genes have a known function matching the annotation |
Why this annotation
This module shows no significant disease association and contains many RNA processing and splicing factors. SRSF2 and SRSF3 are serine/arginine-rich splicing factors. FUS is an RNA-binding protein involved in splicing and transcription. EIF4A3 is a core component of the exon junction complex. RBM25 and RBMX are RNA-binding proteins involved in splicing. CDC5L is a pre-mRNA splicing factor. RSRC2 is an arginine/serine-rich splicing coactivator. PPP1R10 regulates RNA processing. INTS6 is part of the Integrator complex involved in RNA Pol II regulation. ATF4 is a stress-responsive transcription factor. GADD45B is a stress/DNA damage response gene. NFKBIE is an NF-κB inhibitor. DUSP2 is a phosphatase involved in immune signaling. BRD2 is a bromodomain protein involved in transcription. IER5 is an immediate early response gene. The dominant theme is RNA splicing and processing, with some stress-response genes (ATF4, GADD45B, NFKBIE, IER5) that may reflect a coupled transcriptional stress response.
Genes
Most correlated modules
- Pre-mRNA Splicing · correlation 0.76
- Heat Shock Response · correlation 0.73
- Chromatin Transcriptional Regulation · correlation 0.70
- TGF-beta Repression · correlation 0.69
- Mixed Splicing Stress · correlation 0.65
- Mast Cell Activation · correlation 0.64
- Inflammatory Mast Activation · correlation 0.64
- Transcriptional Regulation · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.