Inflammatory Mast Activation
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
This module is upregulated in UC inflammation and contains several mast cell-relevant genes. CTSG (cathepsin G) and CMA1 (chymase) are canonical mast cell serine proteases stored in granules. SOCS3 is a cytokine signaling suppressor induced by inflammatory stimuli. PIM1 is a pro-survival kinase activated downstream of cytokines. IER3 is an immediate early response gene induced by inflammatory signals. TNFRSF9 (4-1BB/CD137) is an activation-induced co-stimulatory receptor. FAIM is an anti-apoptotic gene. RRAD is a stress-responsive GTPase. NRARP modulates Notch/Wnt signaling. PTPN7 is a hematopoietic phosphatase. LEO1 is part of the PAF complex involved in transcription elongation. TMEM88 modulates Wnt signaling. MAFG is a transcription factor. PLPP1 is a lipid phosphatase. The combination of mast cell proteases (CTSG, CMA1), activation markers (TNFRSF9, PIM1, SOCS3, IER3), and the significant upregulation in UC inflammation suggests this module reflects an activated/inflammatory mast cell state. The presence of CTSG and CMA1 alongside activation genes points to a degranulation-associated inflammatory activation program.
Genes
Most correlated modules
- Proteostasis & Translation · correlation 0.84
- Mast Cell Activation · correlation 0.80
- Mixed Housekeeping · correlation 0.76
- Mast Cell Identity · correlation 0.75
- MHC-II Antigen Presentation · correlation 0.73
- Mitochondrial OxPhos · correlation 0.73
- Mast Cell Degranulation · correlation 0.72
- Mast Cell Signaling · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.