Leukotriene Biosynthesis
Gene co-expression module in Mast cells
| Category | Eicosanoid metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 32 genes have a known function matching the annotation |
Why this annotation
SIGLEC8 is a canonical mast cell and eosinophil surface marker. LTC4S (leukotriene C4 synthase) is the terminal enzyme in cysteinyl leukotriene biosynthesis, a defining mast cell eicosanoid pathway. ST3GAL5 (sialyltransferase) modifies glycolipids relevant to mast cell biology. ADCY7 (adenylyl cyclase 7) regulates cAMP in mast cells. PLAT (tPA) is secreted by mast cells. ADGRE2 is an adhesion GPCR expressed on mast cells. CACNA2D1 (calcium channel) supports calcium-dependent degranulation. The module is significantly reduced with CD treatment (delta_treatment_CD -0.301 sig.), suggesting disease-relevant mast cell eicosanoid activity.
Genes
Most correlated modules
- Mast Cell Degranulation · correlation 0.78
- Mast Cell Signaling · correlation 0.75
- Co-transcriptional RNA Processing · correlation 0.68
- Mast Cell Signaling · correlation 0.64
- Mast Cell Identity · correlation 0.64
- Basal Mast Signaling · correlation 0.62
- Immune Checkpoint State · correlation 0.57
- Mast Cell Activation · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.