Glucocorticoid Response
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
The two strongest hub genes are FKBP5 (FK506-binding protein 5, a canonical glucocorticoid-responsive gene used clinically as a GC biomarker) and TSC22D3/GILZ (glucocorticoid-induced leucine zipper, a master anti-inflammatory transcription factor directly induced by glucocorticoids). ZFP36L2 (tristetraprolin family member that destabilizes inflammatory mRNAs, glucocorticoid-regulated) further supports this. The significant delta_treatment_UC signal is consistent with glucocorticoid treatment response. SAP30 (transcriptional repressor) and TXNIP (metabolic stress sensor regulated by GCs) are additional supporting members. This is a tightly coherent glucocorticoid response module in monocytes.
Genes
FKBP5, FMN1, MIS18BP1, NUDT16, SAP30, SMAP2, SPTLC2, SULT1A1, TSC22D3, TXNIP, ZFP36L2
Most correlated modules
- Stress-Adapted Macrophage · correlation 0.69
- M2 Macrophage Polarization · correlation 0.64
- Histone Chromatin Remodeling · correlation 0.63
- Glucocorticoid Transcription · correlation 0.60
- Monocyte Identity · correlation 0.58
- Monocyte-DC Differentiation · correlation 0.56
- Myeloid Activation · correlation 0.55
- Tissue-Resident Macrophage · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.