Type I Interferon Response
Gene co-expression module in Monocytes
| Category | Antiviral |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include IFITM1 (interferon-induced transmembrane protein 1), WARS1 (tryptophanyl-tRNA synthetase, strongly IFN-induced), LY6E (lymphocyte antigen 6E, canonical ISG), IRF9 (interferon regulatory factor 9, master ISG transcription factor), OAS1 (2'-5' oligoadenylate synthetase, antiviral ISG), PSMB10 (immunoproteasome beta subunit, IFN-induced), and PLAAT4 (phospholipase with antiviral roles). MYOF (myoferlin) and HEG1 are less canonical. This is a tight type I interferon / antiviral ISG module. Neighbor to M62 (IFN-γ activation), sharing IFITM family members, supporting an interferon-driven neighborhood.
Genes
HEG1, IFITM1, IRF9, LY6E, MYOF, OAS1, PLAAT4, PSMB10, WARS1
Most correlated modules
- IFN-gamma Monocyte Activation · correlation 0.85
- Immunoproteasome Antigen Processing · correlation 0.81
- Myeloid Innate Receptor Signaling · correlation 0.74
- Type I Interferon Response · correlation 0.69
- Macrophage Differentiation · correlation 0.66
- JAK-STAT IFN Signaling · correlation 0.65
- Non-classical Monocyte · correlation 0.64
- Non-classical Monocyte Migration · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.