Complex I OxPhos
Gene co-expression module in Monocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Small core module led by complex I subunits (NDUFS5, NDUFS6, NDUFS7), plus COX5A and COA3 (complex IV), and mitochondrial MRPL51 and HSD17B10. TPI1 adds glycolysis. This is an energy metabolism / OxPhos program closely linked to M68.
Genes
Most correlated modules
- Respiratory chain OxPhos · correlation 0.92
- Translational biosynthesis · correlation 0.92
- Mitochondrial-splicing housekeeping · correlation 0.91
- Mixed housekeeping metabolism · correlation 0.90
- Translation-OxPhos housekeeping · correlation 0.88
- Proteostasis-trafficking housekeeping · correlation 0.88
- Abundant Small Transcripts · correlation 0.85
- Basal cellular maintenance · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.