Integrin-mediated Migration
Gene co-expression module in Monocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes ITGA5 and ITGB8 encode integrin subunits central to fibronectin-mediated adhesion and ECM engagement. RALGDS is a Ras effector that links integrin signaling to cytoskeletal reorganization and cell migration. TUBB6 provides cytoskeletal support for migration. RAB13 regulates vesicular trafficking during cell polarization and migration. LMNA contributes to nuclear mechanosensing during migration. TNFRSF12A (Fn14/TWEAK-R) promotes monocyte tissue infiltration and remodeling. RGCC and PHLDA1 are stress/survival regulators active in migrating cells. The module is downregulated in remission, consistent with an inflammation-driven monocyte tissue infiltration program. Uniform expression across subsets and strong coherence support a genuine biological program rather than artifact.
Genes
DNAAF1, EIF4E, ITGA5, ITGB8, LMNA, MSC, NRIP3, PHLDA1, PNP, RAB13, RALGDS, RFX2, RGCC, SQLE, TNFRSF12A, TUBB6
Most correlated modules
- Hypoxia Response · correlation 0.65
- Inflammatory Cell Death · correlation 0.63
- Monocyte Immune Tolerance · correlation 0.59
- TREM1 Inflammatory Signaling · correlation 0.57
- NLRP3 Inflammasome Activation · correlation 0.48
- Secretory Vesicle Trafficking · correlation 0.45
- Inflammatory Metabolic Reprogramming · correlation 0.44
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.