IgA-Monocyte Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
FCAR (FcαRI/CD89) is a defining receptor for IgA-mediated monocyte activation and phagocytosis. THBS1 (thrombospondin-1) is secreted by activated monocytes and promotes inflammation and tissue remodeling. SERPINB2 (PAI-2) is strongly induced in inflammatory monocytes and macrophages. CD82 is a tetraspanin upregulated in activated myeloid cells. AREG (amphiregulin) is an EGFR ligand produced by activated monocytes. STK17A is a pro-apoptotic kinase induced in inflammatory states. TRMT6 is an RNA methyltransferase. ASPH is involved in calcium signaling. SLC16A6 is a monocarboxylate transporter. NIBAN2 is stress-responsive. ATP2A3 is a calcium pump. The module is significantly upregulated in UC inflammation and reversed in remission, consistent with IgA receptor-mediated monocyte inflammatory activation.
Genes
AATK, AREG, ASPH, ATP2A3, CD82, FCAR, NIBAN2, SERPINB2, SLC16A6, STK17A, THBS1, TRMT6
Most correlated modules
- Inflammatory Metabolic Reprogramming · correlation 0.69
- Granulocytic Differentiation · correlation 0.63
- Hypoxia Response · correlation 0.62
- Inflammatory Autophagy · correlation 0.60
- NLRP3 Inflammasome Activation · correlation 0.60
- AMPK-FOXO Stress Response · correlation 0.59
- Autophagy Initiation · correlation 0.58
- Wnt/AP-1 Activation · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.