Membrane trafficking biogenesis
Gene co-expression module in Monocytes
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Coherence is moderate. The module combines vesicular trafficking genes: retromer (VPS26A), COPII (SAR1A), COPI (ARFGAP3) and V-ATPase (ATP6V1C1). It also includes lipid synthesis regulators (SREBF1, PCYT1A) and mTORC1/GATOR2 (MIOS). Together these suggest a secretory and membrane biogenesis axis, though weakly defined.
Genes
Most correlated modules
- ER Unfolded Protein Response · correlation 0.85
- Generic transcriptional housekeeping · correlation 0.85
- mRNA splicing machinery · correlation 0.81
- ER protein quality control · correlation 0.81
- Nucleolar Ribosome Biogenesis · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.