Inflammasome Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes CASP1 and CASP4 are the canonical inflammasome effector caspases (pyroptosis/IL-1β processing); CARD16 is a CARD domain protein that modulates caspase-1 activity; ATG3 (autophagy E2-like enzyme); CD53 and CD48 (myeloid surface markers); KYNU (kynurenine pathway, IDO downstream); MTHFD2 (one-carbon metabolism, inflammatory metabolic reprogramming); PSMA4 (proteasome). The co-expression of CASP1, CASP4, and CARD16 strongly defines an inflammasome/pyroptosis program. KYNU links to tryptophan catabolism during inflammation. Upregulated in CD inflammation, reduced in remission. This is a coherent inflammasome activation module in monocytes.
Genes
ATG3, CARD16, CASP1, CASP4, CD48, CD53, KYNU, MTHFD2, PSMA4, SMCO4
Most correlated modules
- Inflammasome Activation · correlation 0.88
- IRF1 Innate Activation · correlation 0.88
- IFN-gamma Response · correlation 0.84
- JAK-STAT IFN Signaling · correlation 0.82
- Inflammatory Monocyte Activation · correlation 0.80
- MHC-II Antigen Presentation · correlation 0.78
- IFN-γ Monocyte Response · correlation 0.78
- Inflammatory Stress Response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.