AMPK-FOXO Stress Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
FOXO3 is a transcription factor that directly activates autophagy genes (BNIP3, ATG genes) and stress response programs. PRKAG2 encodes the gamma-2 regulatory subunit of AMPK, which phosphorylates and activates FOXO3 and ULK1 (neighbor M0). IRF2BP2 is a transcriptional repressor of inflammatory genes in monocytes. JARID2 and TLE3 are epigenetic/transcriptional regulators. FURIN processes pro-inflammatory cytokines. MIDN (midnolin) regulates proteasomal degradation. The AMPK-FOXO3 axis is a canonical stress-responsive transcriptional program that coordinates autophagy and metabolic adaptation, consistent with IBD inflammation upregulation and remission downregulation.
Genes
AHCTF1, C15orf39, FOXO3, FURIN, IRF2BP2, JARID2, MIDN, PRKAG2, TLE3
Most correlated modules
- Inflammatory Autophagy · correlation 0.83
- Autophagy Initiation · correlation 0.82
- Endosomal Sorting · correlation 0.81
- Innate Immune Transcription · correlation 0.76
- Glucocorticoid Transcription · correlation 0.74
- MET Tissue Repair · correlation 0.72
- Wnt/AP-1 Activation · correlation 0.69
- Secretory Vesicle Trafficking · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.