mRNA splicing machinery
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
The hubs are SON, XRCC5, PPIG, DDX46, RSRC2, WBP11 and MED4, all nuclear splicing and transcription factors. The highly detected, long-transcript splicing genes are typical of a nuclear-RNA retention or nuclear-fraction technical axis. Peripheral ESCRT (VPS4B, VPS37C) and myeloid genes (IFNAR1, SLC15A3) are weakly attached. Expression is uniform. This is likely a generic splicing and nuclear housekeeping program that neighbors M117.
Genes
Most correlated modules
- ER-Golgi trafficking · correlation 0.89
- Nuclear RNA processing · correlation 0.86
- Cullin-RING ubiquitination · correlation 0.82
- Membrane trafficking biogenesis · correlation 0.81
- ER protein quality control · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.