Lysosomal autophagy
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 23 genes have a known function matching the annotation |
Why this annotation
This module combines lysosomal and autophagy genes (PPT1, RILP, SQSTM1, LGALS3BP, TCN2) with redox and sulfide metabolism genes (SQOR, GLRX) and monocyte adhesion or receptor genes (FERMT3, SIGLEC14). Its coherence is only moderate and the gene set is mixed. The leaning is toward a lysosome/autophagy maturation program in monocytes.
Genes
Most correlated modules
- Antiviral restriction factors · correlation 0.87
- MHC-II antigen presentation · correlation 0.87
- Lysosomal-scavenger maturation · correlation 0.83
- Classical monocyte identity · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.