IFN-gamma Monocyte Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include SECTM1 (IFN-inducible, CD7 ligand on monocytes), FCGR1A (CD64, IFN-γ-upregulated high-affinity Fc receptor), IFITM3 (interferon-induced transmembrane protein), LILRB4 and LILRB1 (inhibitory leukocyte Ig-like receptors co-regulated with IFN), HLA-F (MHC class I, IFN-regulated), LGALS9 (galectin-9, IFN-induced immunomodulator), TNFRSF14 (HVEM), GAS6 (TAM receptor ligand). BLVRA (biliverdin reductase) links to heme catabolism/anti-inflammatory signaling. Strongly upregulated in both UC and CD inflammation, reduced by CD treatment and in remission. This is a coherent IFN-γ-driven monocyte activation module with co-inhibitory receptor upregulation.
Genes
BLVRA, CYB5A, DRAP1, FCGR1A, GAS6, HLA-F, IFITM3, LGALS9, LILRB1, LILRB4, SECTM1, TNFRSF14
Most correlated modules
- Type I Interferon Response · correlation 0.85
- Immunoproteasome Antigen Processing · correlation 0.83
- Mitochondrial Immune Regulation · correlation 0.72
- Non-classical Monocyte · correlation 0.72
- Monocyte Lipid Handling · correlation 0.70
- Myeloid Innate Receptor Signaling · correlation 0.65
- Non-classical Monocyte State · correlation 0.64
- Macrophage Differentiation · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.