Lysosomal-scavenger maturation
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
Lysosomal proteases dominate the hubs: TPP1, CTSB and CTSH. STAB1 is a scavenger receptor and ATP8B4 is a lipid flippase. ER/secretory chaperones (CANX, TMED10, EMC10) are also present. Together these are typical of monocytes maturing toward macrophages in tissue, with increased lysosomal and scavenging capacity.
Genes
Most correlated modules
- Classical Monocyte Identity · correlation 0.87
- Tec-kinase Signaling · correlation 0.86
- Golgi Vesicle Trafficking · correlation 0.85
- SYK-Rac actin signaling · correlation 0.85
- Classical monocyte identity · correlation 0.84
- Monocyte-Macrophage Transition · correlation 0.84
- AHR-hypoxia adaptation · correlation 0.84
- Lysosomal autophagy · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.