Antiviral restriction factors
Gene co-expression module in Monocytes
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 36 genes have a known function matching the annotation |
Why this annotation
This module is a heterogeneous set of signaling and trafficking genes (SCAPER, TBC1D2B, AFF1, PTK2, BMPR2, RIN2, ARSB, LPIN2). The only thematic thread is a few interferon-inducible antiviral restriction factors: SAMHD1, TRIM56 and FAM111A. A further 16 genes are not shown, and no single dominant program emerges. It is likely a basal transcriptional state shared with the neighboring monocyte modules. I labelled it with low confidence as a tonic antiviral restriction state.
Genes
Most correlated modules
- TFEC lysosomal program · correlation 0.88
- Lysosomal autophagy · correlation 0.87
- mRNA splicing machinery · correlation 0.87
- SYK-Rac actin signaling · correlation 0.85
- Monocyte innate sensing · correlation 0.84
- WASH endosomal recycling · correlation 0.82
- Tec-kinase Signaling · correlation 0.81
- MHC-II antigen presentation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.