ER-Golgi trafficking
Gene co-expression module in Monocytes
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes point to ER-Golgi trafficking and protein homeostasis. SCFD1 (SNARE regulator in ER-Golgi transport), TRAPPC10 (TRAPP tethering complex), RAB2A, RTN4 and PGGT1B (Rab/Rho prenylation) relate to secretory trafficking. DNAJB14, PSMD12, ZFAND6 and SMURF1 relate to proteostasis. Expression is uniform and broad, as in its neighbors, so this is a generic secretory/trafficking housekeeping program; the label is modest given the mixed composition.
Genes
Most correlated modules
- Nuclear RNA processing · correlation 0.89
- mRNA splicing machinery · correlation 0.89
- Long-gene housekeeping · correlation 0.87
- Nuclear RNA processing · correlation 0.87
- Generic transcriptional housekeeping · correlation 0.85
- Metabolic/trafficking housekeeping · correlation 0.84
- Small GTPase signaling · correlation 0.84
- Chromatin regulator transcripts · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.