Biosynthetic Metabolic Activation
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
YBX1 (RNA-binding/translation regulation), NPM1 (nucleolar protein/ribosome biogenesis), IMPDH2 (rate-limiting enzyme in purine biosynthesis), AHCY (S-adenosylhomocysteine hydrolase, methionine/one-carbon cycle), NME1 (nucleoside diphosphate kinase), EEF1B2 (translation elongation factor), PABPC4 (poly-A binding, mRNA stability), NUCKS1 (chromatin remodeling), SLC25A5 (mitochondrial ADP/ATP translocase) collectively represent active biosynthetic metabolism — nucleotide synthesis, translation, and energy production consistent with a proliferative or highly activated metabolic state.
Genes
AHCY, EEF1B2, IMPDH2, NME1, NPM1, NUCKS1, PABPC4, PEBP1, PRDX4, SLC25A5, TMEM14C, TSPAN3, YBX1
Most correlated modules
- Non-classical Monocyte State · correlation 0.82
- Tissue Macrophage Identity · correlation 0.79
- Mitochondrial Immune Regulation · correlation 0.78
- Autophagy Metabolic Stress · correlation 0.78
- IL-18 Inflammasome Response · correlation 0.74
- Monocyte Lipid Handling · correlation 0.74
- Non-classical Monocyte · correlation 0.73
- Complement C1q Macrophage · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.