Nuclear RNA processing
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
The hub genes are ubiquitously expressed housekeeping genes, uniform across subsets. They cover chromatin remodeling (SMARCA5, SMC1A), RNA processing and splicing (THRAP3, U2SURP, DHX36, CTNNBL1), proteostasis and ERAD (UBQLN1, HERPUD2), fatty acid oxidation (DECR1) and retromer function (SNX6). No specific program dominates. The module likely reflects a general transcriptional and nuclear housekeeping capacity axis, which may track cell size or library complexity. It sits beside M181, which carries similar splicing and cohesin genes (SON, PPIG, RAD21), supporting a generic nuclear housekeeping label.
Genes
Most correlated modules
- Generic transcriptional housekeeping · correlation 0.90
- ER-Golgi trafficking · correlation 0.89
- mRNA splicing machinery · correlation 0.86
- Membrane trafficking housekeeping · correlation 0.84
- ER protein quality control · correlation 0.84
- Basal endolysosomal maintenance · correlation 0.84
- Resting myeloid homeostasis · correlation 0.83
- Metabolic/trafficking housekeeping · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.