Classical Monocyte Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
S100A8 and S100A9 (calprotectin heterodimer) are the defining alarmins of classical inflammatory monocytes and neutrophils, acting as DAMPs via TLR4/RAGE. CAPG (macrophage capping protein) is a canonical monocyte/macrophage marker. MCEMP1 marks monocyte subsets. SERPINB1 inhibits neutrophil elastase. VCAN (versican) is expressed by inflammatory monocytes. LYZ (lysozyme) is a classical monocyte antibacterial enzyme. LGALS1 (galectin-1) modulates myeloid inflammation. TALDO1 (transaldolase) supports pentose phosphate metabolism. High mean expression (2.074) and 76.9% detection confirm this is a dominant, broadly expressed classical monocyte inflammatory program. Significantly increased in UC inflammation, decreased in remission.
Genes
CAPG, LGALS1, LYZ, MCEMP1, PDLIM7, S100A8, S100A9, SERPINB1, TALDO1, VCAN
Most correlated modules
- Leukotriene-Alarmin Response · correlation 0.81
- Classical Monocyte Trafficking · correlation 0.76
- Granulocytic Differentiation · correlation 0.75
- Pentose Phosphate Pathway · correlation 0.72
- Myeloid Activation · correlation 0.67
- Multi-lineage Contamination · correlation 0.63
- Monocyte Innate Surveillance · correlation 0.63
- Inflammatory Metabolic Reprogramming · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.