Basal endolysosomal maintenance
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
Weakly themed module with uniform expression. It mixes metabolic, lysosomal and endosomal genes (GLS, SCARB2, RAB39A, ATP10D) with ERAP2 and CASP7, which are modestly IFN-inducible. No coherent single program is evident. It likely reflects a basal or tonic IFN-adjacent housekeeping state that co-varies with the neighboring IFN modules.
Genes
Most correlated modules
- Resting myeloid homeostasis · correlation 0.94
- BTN3A immunoregulatory · correlation 0.92
- Membrane trafficking housekeeping · correlation 0.87
- Generic gene-expression machinery · correlation 0.85
- Nuclear RNA processing · correlation 0.84
- Generic transcriptional housekeeping · correlation 0.83
- WASH endosomal recycling · correlation 0.80
- IFN-gamma response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.