MHC II Antigen Presentation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
CD74, HLA-DRB5, and HLA-DQA2 are core MHC class II antigen presentation machinery genes, highly expressed in monocytes and dendritic cells. CD4 is expressed on monocytes (not just T cells) and participates in MHC II interactions. SASH1 is a scaffold protein involved in TLR4 signaling and monocyte function. RASA4 is a RAS GTPase activating protein. SETDB2 is a histone methyltransferase that suppresses inflammatory gene expression. RTN1 is an ER-shaping protein. ARHGEF10L is a RhoGEF. The dominant signal is MHC II-mediated antigen presentation, upregulated during intestinal inflammation.
Genes
ARHGEF10L, CD4, CD74, HLA-DQA2, HLA-DRB5, RASA4, RTN1, SASH1, SETDB2
Most correlated modules
- Tissue Macrophage Identity · correlation 0.83
- MHC-II Antigen Presentation · correlation 0.82
- Non-classical Monocyte State · correlation 0.81
- Complement C1q Macrophage · correlation 0.69
- Mitochondrial Immune Regulation · correlation 0.69
- Monocyte Lipid Handling · correlation 0.69
- Non-classical Monocyte · correlation 0.68
- ER Stress Response · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.