ER Stress Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
KLF2 and KLF4 are Krüppel-like factors that regulate monocyte quiescence, differentiation, and anti-inflammatory states. DDIT3 (CHOP) and HSPA5 (BiP/GRP78) are canonical ER stress/unfolded protein response markers. CDKN1B (p27) mediates cell cycle arrest. RHOB is a Rho GTPase involved in vesicular trafficking and stress responses. SRSF7 is a splicing factor. GIMAP5 is a lymphocyte survival GTPase (neighbor to M98's GIMAP cluster). RIGI is an innate RNA sensor. ODC1 drives polyamine synthesis. The module is moderate coherence combining KLF-driven monocyte quiescence/differentiation with ER stress signals — consistent with monocytes undergoing differentiation stress in inflamed tissue.
Genes
CDKN1B, CFAP20, DDIT3, GIMAP5, HSPA5, KLF2, KLF4, ODC1, RHOB, RIGI, SRSF7
Most correlated modules
- Non-classical Monocyte State · correlation 0.68
- Heat Shock Response · correlation 0.67
- Co-chaperone Proteostasis · correlation 0.67
- MHC II Antigen Presentation · correlation 0.65
- GIMAP activation · correlation 0.63
- Mitochondrial Immune Regulation · correlation 0.62
- AP-1 Inflammatory Activation · correlation 0.61
- IFN-gamma Monocyte Activation · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.