Inflammatory Metabolic Reprogramming
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
SLC2A3 (GLUT3) is a high-affinity glucose transporter strongly induced in activated/inflammatory monocytes under metabolic stress. ADAM8 is a metalloprotease expressed on activated monocytes promoting inflammation and tissue invasion. ACTN1 (alpha-actinin-1) is a cytoskeletal protein involved in monocyte migration and adhesion. DGAT2 and GPAT3 are lipid synthesis enzymes (diacylglycerol and glycerophosphate acyltransferases), indicating lipid metabolic reprogramming. SLC25A37 (mitoferrin-1) is a mitochondrial iron transporter. EAF1 is an RNA polymerase II elongation factor. MCTP2 is a calcium-binding membrane protein. PTPN7 is a hematopoietic phosphatase. The module is significantly upregulated in both UC and CD inflammation with reversal in remission, suggesting metabolic and cytoskeletal reprogramming in inflammatory monocytes.
Genes
ACTN1, ADAM8, DGAT2, EAF1, GPAT3, MCTP2, PTPN7, SLC25A37, SLC2A3
Most correlated modules
- NLRP3 Inflammasome Activation · correlation 0.70
- IgA-Monocyte Activation · correlation 0.69
- Hypoxia Response · correlation 0.68
- TREM1 Inflammatory Signaling · correlation 0.59
- Wnt/AP-1 Activation · correlation 0.59
- Classical Monocyte Activation · correlation 0.59
- Classical Monocyte Trafficking · correlation 0.49
- Monocyte Innate Surveillance · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.