Immediate Early Activation
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
ARRDC2 (arrestin domain protein, glucocorticoid/stress response), IER5L (immediate early response gene 5-like), RRAS (Ras GTPase, survival signaling), MTSS1 (actin cytoskeletal remodeling), SLC7A7 (cationic amino acid transporter, mTOR/metabolic), TUBB3 (cytoskeletal tubulin), ZNF503 (zinc finger TF). The module is anchored by immediate early/stress response genes (ARRDC2, IER5L) alongside cytoskeletal and metabolic components. Neighbor context (M79 = integrated stress response) supports a stress/early activation program.
Genes
ARRDC2, GALR2, IER5L, MRPL55, MTSS1, NDUFA12, NXT1, RRAS, SLC7A7, SNRNP25, TUBB3, ZNF503
Most correlated modules
- Monocyte Identity · correlation 0.64
- Myeloid Epigenetic Regulation · correlation 0.61
- Inflammatory Monocyte Activation · correlation 0.60
- Stress-Adapted Macrophage · correlation 0.58
- Glucocorticoid Transcription · correlation 0.55
- IFN-gamma Monocyte Activation · correlation 0.53
- G-protein Membrane Remodeling · correlation 0.51
- Endosomal Sorting · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.