Complement Receptor Activation
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
C5AR1 (CD88) and C5AR2 are complement C5a receptors expressed on monocytes/macrophages, mediating complement-driven inflammatory activation. CLEC7A (Dectin-1) is a pattern recognition receptor on myeloid cells recognizing fungal beta-glucans and activating innate immunity. RAB20 is a Rab GTPase involved in phagosomal maturation and endolysosomal trafficking in macrophages. METRNL is a cytokine with anti-inflammatory and tissue-repair roles. ZNF331 is a transcriptional repressor. CSF2RA (GM-CSFR alpha) is expressed on myeloid cells and drives monocyte/macrophage differentiation and activation. AVPI1 is a vasopressin-induced protein. PTPRE is a receptor-type tyrosine phosphatase in myeloid signaling. MAT2A is a methionine adenosyltransferase. The module is upregulated in IBD inflammation with reversal in remission, consistent with complement receptor-mediated phagocytic monocyte activation.
Genes
AVPI1, C5AR1, C5AR2, CLEC7A, CSF2RA, MAT2A, METRNL, PTPRE, RAB20, ZNF331
Most correlated modules
- Wnt/AP-1 Activation · correlation 0.73
- TREM1 Inflammatory Signaling · correlation 0.73
- G-protein Membrane Remodeling · correlation 0.64
- Monocyte Immune Tolerance · correlation 0.59
- NLRP3 Inflammasome Activation · correlation 0.58
- Tissue-destructive Macrophage · correlation 0.57
- Non-canonical NF-κB · correlation 0.51
- Myeloid Epigenetic Regulation · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.