ARF-mediated Trafficking
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 27 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence, indicating a poorly defined module. Hub genes include ARFGEF2 (ARF guanine nucleotide exchange factor involved in vesicular trafficking), CYTH1 (cytohesin-1, ARF activator), DENND5B (DENN domain Rab GEF), and ZFYVE26 (FYVE domain endosomal protein), suggesting a loose association around membrane/vesicular trafficking regulators. However, other genes (RBM6, NFX1, PIAS1, TAF1, NCBP1) are transcriptional/RNA processing factors with no clear trafficking link. The module is too heterogeneous to assign a tight program; the best-supported theme is vesicular/membrane trafficking given the ARF-related hub genes.
Genes
Most correlated modules
- Zinc Finger Transcription · correlation 0.91
- Polycomb Transcription · correlation 0.88
- Mixed Regulatory Background · correlation 0.86
- Mixed Regulatory Background · correlation 0.84
- DNA Damage Response · correlation 0.83
- Rho GEF Signaling · correlation 0.82
- Mixed Regulatory Background · correlation 0.80
- Cell Cycle Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.