DNA Damage Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 13 genes have a known function matching the annotation |
Why this annotation
ATM and TOPBP1 are canonical DNA damage response/genome integrity genes. FBXL5 is involved in ubiquitin-mediated protein degradation. MAP3K1 is a stress-activated MAPK kinase. GIT2 and ZBTB44 are signaling/transcriptional regulators. The ATM-TOPBP1 axis anchors a DNA damage/genome integrity program, though the module is weakly coherent and mixed. KMO (kynurenine pathway) and GANC are metabolic outliers. Weak membership throughout and uniform expression suggest a loosely defined housekeeping/stress-response module.
Genes
Most correlated modules
- Polycomb Transcription · correlation 0.91
- Actin Cytoskeleton · correlation 0.86
- Mixed Regulatory Background · correlation 0.85
- pDC Identity Signaling · correlation 0.85
- ARF-mediated Trafficking · correlation 0.83
- Centrosome Organization · correlation 0.83
- Mixed Regulatory Background · correlation 0.83
- Immune Cell Migration · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.