Immunoproteasome Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes PSMB9 and PSME2 are IFN-gamma-inducible proteasome subunits (immunoproteasome components) central to antigen processing and MHC-I presentation. IFITM2 is a canonical ISG with antiviral membrane restriction activity. NMI (N-Myc interactor) is an IFN-inducible co-activator of STAT signaling. IGSF6 is expressed on myeloid/pDC lineage cells. DRAP1 is a transcriptional repressor. MT2A is a metallothionein induced by stress and cytokines. COX5A is a mitochondrial complex IV subunit. S100A6 and ANXA5 are calcium-binding proteins with immunomodulatory roles. SPATS2L and CHMP5 are less clearly ISG-related. The module sits in a neighborhood of ISG modules (M2, M66, M127, M164), and the immunoproteasome/IFITM2/NMI genes suggest an IFN-driven antigen processing program, though it is more mixed than the other modules. The dominant signal is IFN-inducible antigen processing.
Genes
Most correlated modules
- Type I Interferon · correlation 0.83
- Type I Interferon · correlation 0.78
- Type I Interferon · correlation 0.73
- Type I Interferon · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.