Type I Interferon
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes IFIT3, IFIT1, RSAD2 (Viperin), OASL, IFI6, OAS3, CMPK2, IFIH1 (MDA5), MNDA are all canonical type I interferon-stimulated genes with direct antiviral functions. TNFSF10 (TRAIL) is IFN-inducible and mediates antiviral apoptosis. CD38 is upregulated by IFN in pDCs. NT5C3A and CMPK2 are involved in nucleotide metabolism linked to antiviral responses. This module is a topological neighbor of M2, M127, and M164, all ISG/IFN modules, confirming this classification. TRANK1, TGM1, SLC38A5, and NEXN are less canonical ISGs but appear in IFN-stimulated transcriptomes.
Genes
Most correlated modules
- Type I Interferon · correlation 0.93
- Type I Interferon · correlation 0.77
- Immunoproteasome Response · correlation 0.73
- pDC Innate Sensing · correlation 0.67
- Type I Interferon · correlation 0.65
- Heat Shock Response · correlation 0.57
- DC Maturation Migration · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.