Type I Interferon
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes IFI16, OAS1, OAS2, STAT1, IFI35, BST2, EIF2AK2 (PKR), SAMD9, ADAR, UBE2L6, SP110 are all canonical interferon-stimulated genes. OAS1/OAS2 are antiviral oligoadenylate synthetases; STAT1 is the master transcription factor of IFN signaling; EIF2AK2/PKR mediates antiviral translational arrest; ADAR is an ISG involved in RNA editing; BST2 (Tetherin) restricts viral budding; IFI16 is a cytosolic DNA sensor; SAMD9 is antiviral. TNFSF13B (BAFF) and TRADD are IFN-inducible in pDCs. RBCK1 and UBE2L6 participate in ISGylation. This module is a neighbor of M2, M66, and M164, all ISG modules, confirming the classification.
Genes
Most correlated modules
- Type I Interferon · correlation 0.85
- Type I Interferon · correlation 0.84
- Immunoproteasome Response · correlation 0.83
- Type I Interferon · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.