MHC Class II Presentation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
The top hub genes are HLA-DMA, HLA-DRA, HLA-DPA1, HLA-DPB1, HLA-DRB1 — all MHC class II molecules essential for antigen presentation. PSME1 (proteasome activator PA28alpha) is involved in antigen processing. GPSM3 and NFKBIL1 are encoded in the MHC locus. This module clearly represents MHC class II antigen presentation, which is a known function of plasmacytoid dendritic cells (pDCs), particularly in their antigen-presenting state. Despite weak membership scores (likely due to low coherence metadata), the biological signal is unambiguous. EEF1B2, NEDD8, MRPS12, and PARL are peripheral members that do not fit the core program.
Genes
Most correlated modules
- General Housekeeping · correlation 0.77
- Actin Cytoskeleton · correlation 0.72
- Translation Initiation · correlation 0.63
- Oxidative Stress Response · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.