Oxidative Stress Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include ARHGDIB (Rho GDP dissociation inhibitor beta, immune cell migration/cytoskeletal), GSTP1 and GSTO1 (glutathione S-transferases, oxidative stress/detoxification), ECHS1 (enoyl-CoA hydratase, fatty acid oxidation), CCT7 (chaperonin complex), ITGB2 (integrin beta-2, adhesion/migration), TKT (transketolase, pentose phosphate pathway), IDH2 (TCA cycle), PGAM1 (glycolysis), UQCRH (mitochondrial complex III). The module is mixed but has a notable stress/detoxification theme (GSTP1, GSTO1) alongside metabolic and cytoskeletal genes. In the context of neighboring modules M13 and M33 (housekeeping/cytoskeletal), this module likely represents a related housekeeping program with oxidative stress response emphasis.
Genes
Most correlated modules
- Actin Cytoskeleton · correlation 0.83
- General Housekeeping · correlation 0.82
- Translation Initiation · correlation 0.77
- MHC Class II Presentation · correlation 0.60
- Glycolytic Metabolism · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.