Translation Initiation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 15 of 25 genes have a known function matching the annotation |
Why this annotation
This module is dominated by translation initiation factors (EIF3F, EIF3I, EIF3H), ribosome-associated proteins (RACK1, NPM1, RSL1D1), mitochondrial components (PHB2, VDAC2, MDH2, TUFM, CYC1, SLC25A5, SLC25A6), RNA processing (SNRPB, BTF3, MLF2), and ER/secretory pathway (SSR2, ARF1). The EIF3 complex genes are strong hub genes pointing to translational regulation. The mitochondrial genes (VDAC2, MDH2, TUFM, CYC1, SLC25A5/6) suggest co-expression with oxidative phosphorylation. This is a mixed housekeeping module with translation and mitochondrial emphasis, consistent with the neighborhood context.
Genes
Most correlated modules
- General Housekeeping · correlation 0.84
- Actin Cytoskeleton · correlation 0.78
- Oxidative Stress Response · correlation 0.77
- General Cellular Maintenance · correlation 0.74
- MHC Class II Presentation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.