RNA Processing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Hub genes include MIDEAS (Mediator-associated transcriptional repressor), ZNF451 and ZNF326 (zinc finger transcription factors), SPEN (transcriptional repressor), TARDBP (TDP-43, RNA binding protein), DDX6 (RNA helicase, P-body component), and GRB2 (signaling adaptor). There is a loose theme of transcriptional repression and RNA processing, but the weak membership of all genes and the heterogeneous gene content (zinc fingers, RNA binding, signaling, ER/Golgi via SEC63) indicate a poorly defined residual module. Neighbor context confirms this is part of a cluster of low-coherence background modules.
Genes
Most correlated modules
- pDC Identity & Splicing · correlation 0.90
- Chromatin Remodeling · correlation 0.88
- Chromatin & Ubiquitin · correlation 0.85
- Chromatin Remodeling · correlation 0.84
- Actin Cytoskeleton · correlation 0.82
- Polycomb Transcription · correlation 0.80
- RNA Splicing Regulation · correlation 0.79
- Epigenetic Regulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.