Immune Cell Migration
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 21 genes have a known function matching the annotation |
Why this annotation
MPEG1 (macrophage-expressed gene 1/perforin-2), SELPLG (PSGL-1, selectin ligand for leukocyte rolling/migration), DOCK8 (critical for immune cell migration and pDC survival), BLNK (B cell linker protein, also expressed in pDC precursors), ADA2 (adenosine deaminase 2, expressed in monocytes/macrophages), APBB1IP (hematopoietic cell migration), CPT1A and PPARA (fatty acid oxidation/lipid metabolism). The module mixes immune cell migration/adhesion genes with metabolic genes. SELPLG and DOCK8 support a migration/adhesion theme in immune cells. Weak coherence throughout.
Genes
Most correlated modules
- pDC Identity Signaling · correlation 0.94
- Transcriptional Regulation · correlation 0.86
- IFN Receptor Signaling · correlation 0.83
- DNA Repair Housekeeping · correlation 0.83
- Epigenetic Silencing · correlation 0.83
- Monocyte Chemotaxis · correlation 0.82
- Mixed Regulatory · correlation 0.82
- DNA Damage Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.